To preface, no shade, write whatever you want.

I, personally, treat fandoms very differently when I main a female character than I do a male character. A dude's experience of his gender, no matter his particular presentation, is not going jive with my personal experience of my gender. We are parallel roads. A woman's experience can go same road/intersection/viaduct/oh shit highway why all in the same fic. I am frequently Not Up For That in fic.

So I'll a/b/o all day because scifi genders who cares but I don't do cishet swap or trans fic unless it's a blue moon.